Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.2 pp 223-226
© The Physiological Society 1989
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ADAPTATION AND BURSTING IN NEOCORTICAL NEURONES MAY BE CONTROLLED BY A SINGLE FAST POTASSIUM CONDUCTANCE

N. J. Berman 1, P. C. Bush 1, and R. J. Douglas 1

1 MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OXI 3QT

We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.

Submitted on December 21, 1988
Accepted on January 12, 1989




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