Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.3 pp 291-300
© The Physiological Society 1989
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THE EFFECTS OF CHANGES IN LEFT VENTRICULAR PRESSURE ON RESPIRATORY ACTIVITY IN ANAESTHETIZED DOGS

A. J. Crisp 1, S. M. Tutt 1, K. H. McGregor 1, and R. Hainsworth 1

1 Department of Cardiovascular Studies, University of Leeds, Leeds LS2 9JT

This study was undertaken to determine whether moderate increases in left ventricular systolic pressure in anaesthetized dogs result in changes in respiratory activity. Left ventricular systolic pressure was changed using a preparation in which the applied pressure did not distend the aortic arch and in which left atrial and carotid sinus pressures were held constant. The systemic circulation was perfused at constant flow and respiratory activity was assessed from the phrenic electroneurogram. Increases in aortic root and left ventricular systolic pressures resulted in a decrease in arterial perfusion pressure, no significant change in heart rate and a decrease in phrenic nerve activity. These responses differed from those to changes in carotid sinus pressure, which were decreases in perfusion pressure and heart rate but no significant steady-state change in phrenic activity. Responses to changes in ventricular pressure were obtained to each small step between 16 and 28 kPa (120 and 210 mmHg). Following cervical vagotomy, changes in ventricular pressure resulted in neither respiratory nor vascular responses. These results indicate that left ventricular receptors may play a role in the control of respiration.

Submitted on June 20, 1988
Accepted on November 16, 1988




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