Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.3 pp 367-370
© The Physiological Society 1989
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THE EFFECT OF A CELL-PERMEABLE DIACYLGLYCEROL ANALOGUE ON SINGLE Ca2+ (Ba2+) CHANNEL CURRENTS IN THE INSULIN-SECRETING CELL LINE RINm5F

J. M. Velasco 1 and O. H. Petersen 2

1 Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense, Somosaguas, Madrid, Spain
2 MRC Secretory Control Research Group, Department of Physiology, University of Liverpool, PO Box 147, Liverpool L69 3BX

Depolarization evokes opening of single Ca2+ (Ba2+) channels of the ‘L’ type in the insulin-secreting cell line RINm5F. Stimulation of the cells with the membrane-permeable diacylglycerol analogue didecanoylglycerol (DC10; 5 µg/ml) markedly enhanced the proportion of time the channels spent in the open state during depolarizing voltage pulses. Similar effects have previously been demonstrated with glyceraldehyde stimulation and it therefore seems possible that carbohydrate-evoked cellular Ca2+ uptake is mediated via protein kinase C activation.

Submitted on January 16, 1989
Accepted on January 23, 1989




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