Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.3 pp 371-374
© The Physiological Society 1989
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VASOPRESSIN V1-RECEPTOR BLOCKADE LOWERS ARTERIAL BLOOD PRESSURE IN YOUNG CONSCIOUS LONG-EVANS RATS

L. F. O. Obika 1 and J. F. Laycock 2

1 Department of Physiology & Biochemistry, University of Ilorin, Ilorin, Nigeria
2 Department of Physiology, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF

Young, conscious Long-Evans rats had significantly higher basal mean arterial blood pressure than age-matched Brattleboro rats with hereditary hypothalamic diabetes insipidus, and an intravenous injection of a specific vasopressin V1-receptor blocker significantly decreased the mean arterial pressure in the former animals only. The basal heart rate, which was significantly higher in the Brattleboro rats than in the Long-Evans rats, was unaffected by the vasopressin antagonist in either strain. These results indicate that vasopressin may be important in maintaining normal blood pressure in young rats.

Submitted on February 6, 1989
Accepted on February 23, 1989






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Copyright © 1989 by the The Physiological Society.