Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.4 pp 465-473
© The Physiological Society 1989
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VASOPRESSIN REDUCES FOOD INTAKE IN GOATS

A. H. Meyer 1, W. Langhans 1, and E. Scharrer 1

1 Institut für Veterinär-Physiologie, Universität Zürich, Winterthurerstrasse 260, CH-8057 Zürich, Switzerland

The effect of arginine vasopressin (VP) on cumulative food intake and meal pattern was tested in pygmy goats. VP injected intraperitoneally (I.P.) (0·75, 1·5 and 3·0 µg kg-1 body weight) appeared to reduce food intake in a dose-dependent manner by reducing the size of the first meal and by increasing the first intermeal interval (IMI). The hypophagic effect of VP was reversed by both a V1-receptor antagonist and an agr-adrenergic antagonist. Exogenous VP (0·75 and 1·5 µg kg-1 body weight I.P.) produced increases in plasma VP concentration which also may occur in stressful situations. VP might therefore be related to stress-induced anorexia.

Submitted on October 24, 1988
Accepted on February 8, 1989






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Copyright © 1989 by the The Physiological Society.