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STIMULATION OF OVINE PLACENTAL CALCIUM TRANSPORT BY PURIFIED NATURAL AND RECOMBINANT PARATHYROID HORMONE-RELATED PROTEIN (PTHrP) PREPARATIONS
1 Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT
2 St Vincent's Institute of Medical Research, University of Melbourne, Australia
3 Department of Veterinary Clinical Studies, University of Melbourne, Australia
4 Genentech Inc., San Francisco, USA
Perfusion in situ of the placenta of previously thyroparathyroidectomized fetal lambs has been used to compare the ability of various forms of parathyroid hormone-related protein (PTHrP) to stimulate placental calcium transport. Whereas PTHrP (1-34) was without effect, PTHrP (1-141) was active but usually after a delay of up to 1 h, in common with the effect noted when using extracts of fetal parathyroid glands. In contrast, PTHrP (1-84) and PTHrP (1-108), tended to show a more rapid stimulatory action. It is suggested that post-translational processing of PTHrP (1-141) may occur as an activating step in the placenta in vivo.
Submitted on March 23, 1989
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