Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.4 pp 557-560
© The Physiological Society 1989
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AMILORIDE REDUCES MATERNOFETAL CLEARANCE OF SODIUM ACROSS THE NEAR-TERM RAT PLACENTA

D. E. Atkinson 1, C. P. Sibley 1, and N. R. Robinson 1

1 Departments of Child Health and Physiological Sciences, St Mary's Hospital, University of Manchester, Manchester M13 0JH

The effect of amiloride on unidirectional maternofetal clearance across the perfused placenta has been studied in rats at 21 days gestation. A bolus dose of 1 mg kg-1 followed by an infusion of 0·6 mg h-1 into the maternal circulation caused a significant (P lang 0·02) decrease in 22Na clearance by 8%, whilst having no effect on the clearance of 51Cr-EDTA; a ten times higher dose of amiloride (10 mg kg-1, 6 mg h-1) did not reduce 22Na clearance further. Similar administration of an equivalent volume of saline to control animals showed no effect on either Na+ or Cr-EDTA clearances.

Submitted on April 13, 1989
Accepted on April 27, 1989




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[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the The Physiological Society.