Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.4 pp 565-567
© The Physiological Society 1989
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ROLE OF CHLORIDE IN HYPERTONICITY-INDUCED CONTRACTURES OF RAT SOLEUS MUSCLE

J. D. Bruton 1

1 Department of Physiology, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

The role of chloride in contractures induced in rat soleus muscle by mannitol-, sucrose- or urea-containing hypertonic solutions was investigated. Replacement of chloride with nitrate, sulphate or perchlorate reduced the amplitude of mannitol- and sucrose-induced contractures, and the first phase of contractures induced by urea. Addition of 9-anthracene carboxylic acid had similar effects. The presence of diazepam increased the amplitude of ‘hypertonic’ contractures. The results show that chloride is important in the development of hypertonic contractures.

Submitted on May 4, 1989
Accepted on May 16, 1989






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