Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.4 pp 573-576
© The Physiological Society 1989
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THE DISTRIBUTION OF beta-ADRENOCEPTORS IN HUMAN CERVIX

E. M. Whitaker 1, A. J. Nimmo 1, J. F. B. Morrison 1, N. R. Griffin 2, and M. Wells 2

1 Department of Physiology, University of Leeds, Leeds LS2 9NQ
2 Department of Pathology, University of Leeds, Leeds LS2 9NQ

The distribution of beta-adrenoceptors in sections of human cervix taken at the proliferative phase of the menstrual cycle was studied using light-microscopic autoradiography. The radioligand [125I]iodo-cyanopindolol (125ICYP) was used to identify specific binding sites. Moderate density of labelling by 125ICYP was seen over smooth muscle and blood vessels. The most intense labelling, however, was seen over glands and surface columnar epithelium. The association of beta-adrenoceptors with glands and surface columnar epithelium suggests a possible adrenergic regulation of secretory function in the cervix.

Submitted on May 2, 1989
Accepted on May 12, 1989




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Copyright © 1989 by the The Physiological Society.