Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.5 pp 715-726
© The Physiological Society 1989
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AGE-RELATED EFFECTS OF FATIGUE AND RECOVERY FROM FATIGUE IN RAT MEDIAL GASTROCNEMIUS MUSCLE

A. De Haan 1, M. A. N. Lodder 1, and A. J. Sargeant 1

1 Department of Exercise Physiology and Health Science, Faculties of Human Movement Sciences and Medicine, Vrije Universiteit and Universiteit van Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

Force-velocity, power-velocity and unloaded shortening data were obtained from in situ medial gastrocnemius muscle-tendon complexes (stimulated at 60 Hz) with intact circulation of mature male rats (sim 125 days old). Measurements were carried out at the end of a long (15 s) contraction (fatigued muscles) or with a short (1 s) contraction either in the fresh state (fresh muscles) or in muscles which had recovered for 15 min after a long contraction. Compared to the fresh state fatigue reduced isometric force by 57%, maximal shortening velocity by sim 40% and maximal power output by 81%. These reductions were similar to data previously obtained with younger rats (40 days old). However, the velocity data of the muscles which had recovered for 15 min after a long contraction showed a greater reduction in the mature rats. This difference between the two age groups together with a difference in the changes in the initial parts of the isometric force-time curves suggest an age-dependent response of the fast-fatigable fibre population of these mixed muscles. In a separate series of experiments the underlying mechanism of the recovery from fatigue was studied in a group of young rats. Fatigue was induced with five long (15 s) contractions (each at 5 min intervals). The recovery of isometric force and power output was monitored with short contractions which indicated a plateau of recovery but the absolute values were still reduced after 60 min (85 and 71% of pre-fatigue values, respectively). Phosphocreatine concentration recovered rapidly, whereas the ATP concentration was still markedly reduced after 1 h of recovery. The time courses of recovery of inosine-5'-monophosphate (IMP) and lactate concentrations resembled those of force and power output. Thus it is possible that age-dependent differences in IMP and/or lactate production may play a role in fatigue and recovery from fatigue.

Submitted on December 13, 1988
Accepted on March 30, 1989




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