Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.5 pp 747-750
© The Physiological Society 1989
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EXTRACELLULAR MAGNESIUM REGULATES ACETYL-CHOLINE-EVOKED AMYLASE SECRETION AND CALCIUM MOBILIZATION IN RAT PANCREATIC ACINAR CELLS

Roger Lennard 1, Leo P. Francis 1, and Jaipaul Singh 1

1 School of Applied Biology, Lancashire Polytechnic, Preston PR1 2TQ

Application of ACh (10-6 M) to the isolated rat pancreas elicited large increases in amylase secretion, radiolabelled 45Ca influx and cytosolic free Ca2+ levels in zero and normal (1·1 mM) extracellular magnesium (Mg2+). Elevated (10 mM) Mg2+ significantly (P lang 0·001) reduced the ACh-induced amylase output and Ca2+ mobilization. Similarly, ACh (10-5 M) caused a transient increase in 45Ca efflux from pre-loaded pancreatic segments in normal Mg2+ compared with the much reduced effect in elevated Mg2+. The results suggest that a modification in Mg2+ influences ACh-evoked amylase secretion by regulating Ca2+ mobilization.

Submitted on May 18, 1989
Accepted on July 7, 1989






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Copyright © 1989 by the The Physiological Society.