Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.5 pp 751-753
© The Physiological Society 1989
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THE EFFECTS OF ACUTE AND CHRONIC EXPOSURE TO ETHANOL ON GLUCOSE UPTAKE BY RAT JEJUNAL BRUSH-BORDER MEMBRANE VESICLES

Fawzia Al-Balool 1 and E. S. Debnam 1

1 Department of Physiology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF

Rats were pair-fed for 28-32 days a nutritionally adequate liquid control diet or an isocaloric diet containing ethanol (5 % v/v). Brush-border membrane vesicles were prepared from jejunal mucosa and Na+-dependent D-glucose accumulation was measured using sugar concentrations of 0·2-1·0 mmol l-1. In separate experiments the effects of acute ethanol exposure on glucose uptake by vesicles prepared from chow-fed rats were determined. Chronic ethanol ingestion enhanced Na+-gradient-dependent glucose uptake. In contrast, incubation of vesicles with alcohol (4 % v/v). reduced active uptake of the sugar.

Submitted on July 5, 1989
Accepted on July 19, 1989






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Copyright © 1989 by the The Physiological Society.