Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.6 pp 943-945
© The Physiological Society 1989
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THE MODULATION OF FORCE IN ISOLATED RAT EGTATREATED ANOCOCCYGEUS MUSCLE BY PHOSPHATE, CYCLIC AMP AND NORADRENALINE

C. A. Crichton 1, G. L. SMITH 1, D. J. Miller 1, and J. C. McGrath 1

1 Institute of Physiology, University of Glasgow, Glasgow G12 8QQ

Saponin treatment is commonly used to permeabilize the surface membrane of muscle cells. Incubation of isolated rat anococcygeus for 4 h in a low Ca2+ and low Mg2+ solution resulted in the muscle responding to Ca2+, phosphate and cyclic AMP in a similar way to a saponin-treated muscle. However, unlike saponin-treated preparations, the maximal calcium-activated force was stable for many hours and the addition of noradrenaline caused contracture. These properties would permit this preparation to be used to study aspects of receptor-mediated excitation-contraction coupling.

Submitted on August 14, 1989
Accepted on September 5, 1989






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Copyright © 1989 by the The Physiological Society.