Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.6 pp 947-950
© The Physiological Society 1989
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A COMPARISON OF CONTRACTILE FUNCTION IN LARGE AND SMALL PULMONARY ARTERIAL VESSELS OF THE RAT

Richard M. Leach 1, Charles H. C. Twort 1, Ian R. Cameron 1, and Jeremy P. T. Ward 1

1 Department of Medicine, United Medical and Dental Schools, Lambeth Palace Road, London SE1 7EH

The contractile function of rat pulmonary arterial vessels, ranging in internal diameter from 100 to 2000 µm, was studied in vitro using a small vessel myograph. It was found that vessels with a diameter of 200-400 µm produced considerably more force for a given intervention than those either smaller (lang100-2000 µm) or larger (400-2000 µm). It is suggested that these vessels may play an important role in the generation of pulmonary vascular resistance.

Submitted on August 18, 1989
Accepted on August 30, 1989




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Copyright © 1989 by the The Physiological Society.