Experimental Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Quarterly Journal of Experimental Physiology 74.6 pp 959-962
© The Physiological Society 1989
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robertson, B. E.
Right arrow Articles by Nye, P. C. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robertson, B. E.
Right arrow Articles by Nye, P. C. G.

TOLBUTAMIDE REVERSES HYPOXIC PULMONARY VASOCONSTRICTION IN ISOLATED RAT LUNGS

B. E. Robertson 1, D. J. Paterson 1, C. Peers 1, and P. C. G. Nye 1

1 University Laboratory of Physiology, Parks Road, Oxford OX1 3PT

We have investigated the effects of tolbutamide on the hypoxic vasoconstriction of isolated, perfused rat lungs. We did this because lowered ATP may link hypoxia and constriction, and tolbutamide mimics the effects of ATP in other tissues by blocking ATP-sensitive potassium (ATP-K) channels. Pulmonary vasoconstriction, induced by lowering the oxygen of the gas ventilating the lungs from 95 to 2 %, was always reduced or abolished by tolbutamide (1·7 x 10-4-8·5 x 10-3 M). High concentrations (greater than or equal to 10-3 M) of diazoxide, a drug that opens ATP-K channels, dramatically constricted the pulmonary vasculature and this effect was also reversed by tolbutamide. The opening of ATP-K channels may therefore underlie hypoxic pulmonary vasoconstriction.

Submitted on September 1, 1989
Accepted on September 12, 1989






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1989 by the The Physiological Society.