Experimental Physiology
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Experimental Physiology 75.2 pp 275-277
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 2, 275-277
Copyright © 1990 by The Physiological Society

Article

Unreliability of lithium clearance as a marker of proximal tubular function during haemorrhagic hypotension in the rat

SJ Walter and DG Shirley

Fractional lithium excretion (FELi) was measured before and after hypotensive haemorrhage (15 ml (kg body wt)-1) in anaesthetized Brattleboro rats; simultaneously, micropuncture collections were made from late proximal convoluted tubules. Micropuncture data indicated that fractional reabsorption in the proximal convoluted tubules was not affected significantly by haemorrhage, whereas FELi fell from 0.25 +/- 0.02 (mean +/- S.E.M.; control period) to 0.03 +/- 0.01. In time-control animals, no significant change in either variable was observed. These results suggest that lithium clearance is an unreliable marker of proximal tubular function during haemorrhagic hypotension.




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Copyright © 1990 by the The Physiological Society.