Experimental Physiology
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Experimental Physiology 75.3 pp 411-413
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 3, 411-413
Copyright © 1990 by The Physiological Society

Article

Endometrial electrogenic ion secretion in the rat is modulated by prostaglandins

A Sebkhi and RJ Levin

In the isolated rat uterus, maximal increases in endometrial electrogenic ion secretion produced by luminal prostaglandins (PGs) E1, E2 and F1, and measured as the short-circuit current (Isc), displayed bell-shaped dose-response curves. PGE1 was the most potent and PGF1 the least. The dose-response relationships for the decrease in resistance were curvilinear for PGE1 and PGF1 but bell shaped for PGE2. PGF1 was the most potent at inhibiting the increase in Isc induced by serosal adrenaline but not in inhibiting the fall in tissue resistance. The electrogenic ion secretion of rat endometrium is modulated by prostaglandins via a mechanism also influenced by adrenaline.




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Copyright © 1990 by the The Physiological Society.