Experimental Physiology
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Experimental Physiology 75.4 pp 601-604
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 4, 601-604
Copyright © 1990 by The Physiological Society

Article

Vasoactive intestinal peptide stimulation of adenylate cyclase activity in isolated rabbit renal arterial microvessels

NM Griffiths and NL Simmons

Vasoactive intestinal peptide (VIP) at a concentration of 1 microM stimulates adenylate cyclase (AC) in isolated rabbit renal preglomerular arterial vessels by 3.9 +/- 1.3 fold (n = 6) over basal values. A comparable stimulation of AC was observed with prostaglandin E1. Half-maximal VIP-stimulated activity was observed at 7.2 +/- 3.5 nM (n = 6), which was increased to 17.4 +/- 4.4 nM by 10 microM-(4Cl-D-Phe6,Leu17)VIP, a VIP-receptor antagonist.




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