Experimental Physiology
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Experimental Physiology 75.4 pp 613-616
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 4, 613-616
Copyright © 1990 by The Physiological Society

Article

Abnormal expression of dipeptidylpeptidase IV activity in enterocyte brush-border membranes of children suffering from coeliac disease

MW Smith and AD Phillips

Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compared with previous results showing coeliac disease to inhibit disaccharidase activities selectively.




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Copyright © 1990 by the The Physiological Society.