Experimental Physiology
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Experimental Physiology 75.5 pp 725-728
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 5, 725-728
Copyright © 1990 by The Physiological Society

Article

Coronary myogenic responses to abrupt changes in aortic blood pressure in anaesthetized dogs

M Dambrosio, D Gattullo, RJ Linden, G Losano, P Pagliaro, and P Vono

A transient increase in coronary transmural pressure was produced in anaesthetized dogs by occlusion of the descending thoracic aorta. Aortic blood pressure (ABP), left ventricular pressure and coronary flow were measured; coronary vascular resistance (CVR) was calculated. Results were similar in innervated and denervated hearts. Occlusion for 10 and 20 s resulted in no change in CVR for 15 s, followed by a metabolic dilatation attributable to enhanced oxygen demand; after release the fall in ABP resulted in an immediate increase in CVR, caused by vascular elastic recoil, followed by hyperaemia.




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Copyright © 1990 by the The Physiological Society.