Experimental Physiology
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Experimental Physiology 75.5 pp 729-731
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 5, 729-731
Copyright © 1990 by The Physiological Society

Article

Dissociation between plasma concentrations of thyroxine and insulin-like growth factor-I

MJ Dauncey, A Morovat, BT Rudd, and RA Shakespear

The relation between plasma concentrations of thyroxine (T4) and insulin-like growth factor-I (IGF-I) has been examined in young, growing pigs under controlled conditions of energy intake. Compared with euthyroid controls, plasma levels of IGF-I were significantly elevated (P less than 0.005) both in hypothyroid animals on the same food intake and in hyperthyroid animals on double the food intake. There was however no increase in IGF-I in a hyperthyroid group on the control level of intake. Contrary to previous reports in which energy intake was not controlled, it is concluded that there is no simple correlation between plasma concentrations of T4 and IGF-I.




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Copyright © 1990 by the The Physiological Society.