Experimental Physiology
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Experimental Physiology 75.5 pp 733-736
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 5, 733-736
Copyright © 1990 by The Physiological Society

Article

Development of chronic secondary epileptic foci following intrahippocampal injection of tetanus toxin in the rat

JG Jefferys and RM Empson

It is known that injecting a minute dose of tetanus toxin into rat hippocampus leads to a chronic epileptic syndrome. Here we describe the development of secondary, 'mirror' epileptic foci in the hippocampus contralateral to a single injection of the toxin (12 mouse LD50). This was detected in slices in vitro prepared 6 to 56 days after injection, both as evoked after-discharges and as spontaneous synchronous bursts that were mainly restricted to subregions CA3b and c.




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Copyright © 1990 by the The Physiological Society.