Experimental Physiology
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Experimental Physiology 75.6 pp 843-846
© The Physiological Society 1990
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Experimental Physiology, Vol 75, Issue 6, 843-846
Copyright © 1990 by The Physiological Society

Article

Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes

R Bonvallet, F Lemtiri-Chlieh, and O Rougier

The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch-clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between -50 and +30 mV. The forskolin-induced increase of INa was mimicked by 1,9-dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.




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Copyright © 1990 by the The Physiological Society.