The effects on baroreceptor reflexes of bilateral application of the C fibre neurotoxin, capsaicin, to the cervical vagi have been investigated in decerebrate ferrets. Baroreflex sensitivity was estimated from the relationship between cardiac interval and systolic blood pressure following I.V. infusion of phenylephrine. Control responses to phenylephrine were fitted by two linear slopes with an initial shallow slope, a, followed by a steeper slope, b. Capsaicin abolished slope b and the resulting relationship was best fitted by a single regression with a slope not significantly different from that of the control response a. This suggests that a significant proportion of the baroreflex response induced by phenylephrine is mediated by cardiopulmonary receptors attached to vagal afferent C fibres.

This article has been cited by other articles:

				V. A. Braga, M. A. Burmeister, R. V. Sharma, and R. L. Davisson Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1168 - R1174. [Abstract] [Full Text] [PDF]

				D. Song, K. A. Sharkey, D. R. Breitman, Y. Zhang, and S. S. Lee Disordered central cardiovascular regulation in portal hypertensive and cirrhotic rats Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G420 - G430. [Abstract] [Full Text] [PDF]