Experimental Physiology
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Experimental Physiology 76.4 pp 533-537
© The Physiological Society 1991
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Experimental Physiology, Vol 76, Issue 4, 533-537
Copyright © 1991 by The Physiological Society

Article

Intracellular degradation of newly synthesized casein in perfused rat mammary gland

CJ Wilde, MA Kerr, and DT Calvert

Degradation of newly synthesized casein in rat mammary gland perfused in situ was measured by a pulse-chase method using [3H]proline. Casein degradation during secretion was observed in the absence of prolactin, but not with prolactin present. Partial inhibition by chloroquine showed that hormone-dependent degradation occurred intracellularly by a lysosomal mechanism. The study indicates that this post-translational mechanism is a physiological regulator of net casein secretion.




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Copyright © 1991 by the The Physiological Society.