Experimental Physiology
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Experimental Physiology 77.1 pp 225-228
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 1, 225-228
Copyright © 1992 by The Physiological Society


Article

Cholecystokinin-induced c-fos expression in the rat brain stem is influenced by vagal nerve integrity

KA Fraser and JS Davison

Exogenous cholecystokinin (CCK) activates brain stem neurons in the area postrema and nucleus of the tractus solitarius, primarily in regions where vagal afferent fibres terminate. The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.


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