Experimental Physiology
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Experimental Physiology 77.3 pp 509-511
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 3, 509-511
Copyright © 1992 by The Physiological Society

Article

Evidence for involvement of nitric oxide in the non-adrenergic non-cholinergic (NANC) relaxation of human lower oesophageal sphincter muscle strips

HC McKirdy, ML McKirdy, MJ Lewis, and RW Marshall

Electrical field stimulation of circular muscle strips from human lower oesophageal sphincter reveals a predominant relaxation response. This relaxation is non-adrenergic non-cholinergic (NANC). The nitric oxide synthesis-blocking agent N omega-nitro-L-arginine (10-100 microM) reduces or abolishes this NANC relaxation, suggesting involvement of nitric oxide in the response.


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