Experimental Physiology
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Experimental Physiology 77.3 pp 525-528
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 3, 525-528
Copyright © 1992 by The Physiological Society

Article

Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes

MW Smith, A Turvey, and TC Freeman

Glucose uptake by rabbit intestine has been shown to be confined to the upper two-thirds of jejunal villi. Inhibition by phloridzin shows most of this transport to take place through the Na(+)-glucose linked transporter (SGLT1). Parallel measurements on the other hand show SGLT1 mRNA expression to increase rapidly as enterocytes reach the crypt-villus junction. Levels of SGLT1 mRNA then remain elevated in all villus enterocytes. These results provide direct evidence that SGLT1-mediated glucose transport is subject to post-transcriptional control.


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Copyright © 1992 by the The Physiological Society.