The steady-state flow of fluid across the wall of the isolated rabbit common carotid artery has been measured in the presence and absence of flow within the lumen of the vessel. The perfusate solution contained either 10 or 40 mg ml-1 albumin and transmural flux was measured by monitoring the rate of movement of fluid into a chamber enclosing the artery. Vasomotion was minimized by the inclusion of the vasodilator sodium nitrite in both the perfusate and the outer bathing solution. A relatively slow luminal flow caused a reversible increase in the transmural flux by 20-30% relative to the value in the absence of flow. The mechanism responsible for the increase is not clear, but since it was not affected by the H1 antagonist, mepyramine, it would not appear to have been mediated by histamine release.

This article has been cited by other articles:

				M.-h. Kim, N. R. Harris, and J. M. Tarbell Regulation of hydraulic conductivity in response to sustained changes in pressure Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2551 - H2558. [Abstract] [Full Text] [PDF]

				M.-h. Kim, N. R. Harris, and J. M. Tarbell Regulation of capillary hydraulic conductivity in response to an acute change in shear Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2126 - H2135. [Abstract] [Full Text] [PDF]

				L. DeMaio, J. M. Tarbell, R. C. Scaduto Jr., T. W. Gardner, and D. A. Antonetti A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H731 - H741. [Abstract] [Full Text] [PDF]

				J. A. Florian, J. R. Kosky, K. Ainslie, Z. Pang, R. O. Dull, and J. M. Tarbell Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells Circ. Res., November 14, 2003; 93 (10): e136 - e142. [Abstract] [Full Text] [PDF]

				M. Civelek, K. Ainslie, J. S. Garanich, and J. M. Tarbell Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism J Appl Physiol, December 1, 2002; 93(6): 1907 - 1917. [Abstract] [Full Text] [PDF]

				L. DeMaio, Y. S. Chang, T. W. Gardner, J. M. Tarbell, and D. A. Antonetti Shear stress regulates occludin content and phosphorylation Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H105 - H113. [Abstract] [Full Text] [PDF]

				Y. S. Chang, J. A. Yaccino, S. Lakshminarayanan, J. A. Frangos, and J. M. Tarbell Shear-Induced Increase in Hydraulic Conductivity in Endothelial Cells Is Mediated by a Nitric Oxide-Dependent Mechanism Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 35 - 42. [Abstract] [Full Text] [PDF]

				J. M. Tarbell, L. Demaio, and M. M. Zaw Effect of pressure on hydraulic conductivity of endothelial monolayers: role of endothelial cleft shear stress J Appl Physiol, July 1, 1999; 87(1): 261 - 268. [Abstract] [Full Text] [PDF]