Experimental Physiology
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Experimental Physiology 77.4 pp 645-648
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 4, 645-648
Copyright © 1992 by The Physiological Society

Article

Enhanced electrogenic secretion in vitro by small intestine from glucagon-treated rats: implications for the diarrhoea of starvation

A Lane and RJ Levin

Glucagon treatment of fed rats (50 micrograms I.P. every 6 h for 3 days) induces significant increases in vitro of the basal short-circuit currents of the jejunum (52%) and proximal ileum (81%) and in their electrogenic secretory responses to stimulation by bethanechol, a muscarinic agonist. The results support a role for glucagon in the intestinal hypersecretion observed in starvation and nutrient deprivation.




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Copyright © 1992 by the The Physiological Society.