Experimental Physiology
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Experimental Physiology 77.4 pp 653-656
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 4, 653-656
Copyright © 1992 by The Physiological Society


Article

Is the milk-fat-globule membrane a model for mammary secretory cell apical membrane?

DB Shennan

K+(Rb+) uptake by milk-fat-globule membrane (MFGM) vesicles and skim-milk membrane vesicles isolated from bovine milk has been studied. The K+(Rb+) permeability of MFGMs was very low in both high- and low-strength ionic media. In contrast, skim-milk membranes displayed a significant permeability to K+(Rb+). The results suggest that these membrane preparations do not originate from the same source on the mammary secretory cell and also call into question the suitability of the MFGM as a model for the apical membrane of mammary epithelial cells.


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D. B. Shennan and M. Peaker
Transport of Milk Constituents by the Mammary Gland
Physiol Rev, July 1, 2000; 80(3): 925 - 951.
[Abstract] [Full Text] [PDF]




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