Experimental Physiology
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Experimental Physiology 77.5 pp 761-764
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 5, 761-764
Copyright © 1992 by The Physiological Society

Article

Intracerebroventricular angiotensin II-induced thirst and sodium appetite in rat are blocked by the AT1 receptor antagonist, Losartan (DuP 753), but not by the AT2 antagonist, CGP 42112B

MJ Beresford and JT Fitzsimons

In the rat, intakes of water and 1.8% NaCl induced by I.C.V. angiotensin II were inhibited by prior I.C.V. injection of the angiotensin subtype 1 receptor antagonist, Losartan, but not by the subtype 2 receptor antagonist, CGP 42112B. Drinking induced by I.C.V. carbachol was unaffected by either antagonist.


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