Experimental Physiology
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Experimental Physiology 77.6 pp 925-928
© The Physiological Society 1992
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Experimental Physiology, Vol 77, Issue 6, 925-928
Copyright © 1992 by The Physiological Society

Article

Voltage-sensitive elevation of cytosolic [Ca2+] in guinea-pig cardiac myocytes elicited by calcitonin gene-related peptide

JS Gill, BS Moonga, CL Huang, F Lu, M Zaidi, and AJ Camm

We have studied the effect of the 37-amino acid cardioactive peptide, calcitonin gene-related peptide (CGRP) on cytosolic [Ca2+] in guinea-pig ventricular myocytes following depolarization. Cytosolic [Ca2+] was measured in single myocytes using fura-2. The application of 20 mM K+ led to a transient rise of cytosolic [Ca2+] followed by an exponential decline. The subsequent application of 2 nM CGRP resulted in a marked increase in cytosolic [Ca2+]. In contrast, no such response was obtained without prior depolarization. The results suggest a basis for the cardiotropic effects of CGRP through an influence on cytosolic [Ca2+].


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M.-H. Huang, P. R. Knight III, and J. L. Izzo Jr.
Ca2+-induced Ca2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R259 - R264.
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