Experimental Physiology
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Experimental Physiology 78.4 pp 545-548
© The Physiological Society 1993
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Experimental Physiology, Vol 78, Issue 4, 545-548
Copyright © 1993 by The Physiological Society

Article

The role of the sodium pump and sodium-calcium exchange in recovery from calcium overload in guinea-pig ventricular myocytes

KK Minezaki and RA Chapman

A marked increase in [Ca2+]i is provoked in isolated guinea-pig ventricular myocytes by return to normal Tyrode solution after a period of exposure to fluid free of divalent cations. When the sarcolemma of the myocyte remains intact, [Ca2+]i falls back towards initial levels over the next 5 to 10 min in spite of the strong irreversible contracture. This recovery fails to occur if either the Na+ pump or Na(+)-Ca2+ exchange is inhibited once [Ca2+]i has risen.


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 Cardiovasc ResHome page
K. Ban, S. Handa, and R. A Chapman
On the mechanism of the failure of mitochondrial function in isolated guinea-pig myocytes subjected to a Ca2+ overload
Cardiovasc Res, December 1, 1999; 44(3): 556 - 567.
[Abstract] [Full Text] [PDF]


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