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We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the appearance of crater-like holes, a reduction in granule size and disruption of the cell membrane. The implications of these findings are discussed.
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N. BAUDRY, G. DANIALOU, J. BOCZKOWSKI, and E. VICAUT In Vivo Study of the Effect of Systemic Hypoxia on Leukocyte-Endothelium Interactions Am. J. Respir. Crit. Care Med., August 1, 1998; 158(2): 477 - 483. [Abstract] [Full Text] [PDF] |
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