Experimental Physiology
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Experimental Physiology 79.1 pp 107-110
© The Physiological Society 1994
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Experimental Physiology, Vol 79, Issue 1, 107-110
Copyright © 1994 by The Physiological Society

Article

Reduction in the contraction and intracellular calcium transient of single rat ventricular myocytes by gadolinium and the attenuation of these effects by extracellular NaH2PO4

H Ward and E White

Gadolinium (Gd3+) is the most commonly used blocker of stretch-activated channels (SACs). The actions of Gd3+ in unstretched adult heart were investigated by observing its effects on the contraction and intracellular calcium transient of single rat ventricular myocytes. We found that Gd3+ caused a profound reduction in both these parameters at doses typically used to block SACs. However, the actions of Gd3+ were severely attenuated by the presence of 0.33 mM NaH2PO4, which possibly chelates the Gd3+ ion.


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