The current investigation, for which ethical permission was obtained, was designed to assess the putative neurophysiological effects of low intensity (9.6 J/cm2) laser (830 nm) irradiation upon conduction latencies in the human median nerve in vivo. Antidromic nerve conduction studies were performed on the non-dominant arms of healthy human volunteers (n = 51), who were each assigned to one of a variety of laser, placebo or control groups under randomized, blinded conditions. Analysis of negative peak latency differences using analysis of variance showed small (approximately 0.4 ms) but significant increases in latencies as a result of direct laser irradiation, and, where two-site recording was used, distal to the site of irradiation. No such differences were seen in the other experimental groups. These results show that laser irradiation applied to intact skin at the parameters used here may produce a direct, localized effect upon conduction in underlying nerves.

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