Experimental Physiology
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Experimental Physiology 79.2 pp 261-264
© The Physiological Society 1994
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Experimental Physiology, Vol 79, Issue 2, 261-264
Copyright © 1994 by The Physiological Society

Article

Presynaptic inhibition by neuropeptide Y of slow inhibitory synaptic transmission in submucous neurones of guinea-pig caecum

SM Cunningham, S Mihara, and GM Lees

The occurrence and disposition of immunoreactivity for neuropeptide Y (NPY) was investigated in the submucosa of guinea-pig caecum. There were few NPY-immunoreactive neurones but intraganglionic varicose fibres were so numerous and strongly immunoreactive that some somata may have been obscured. In each neurone tested, exogenous application of NPY (1-100 nM) depressed the duration and amplitude of the slow inhibitory postsynaptic potential. In contrast, NPY (1-300 nM) had no effects on the resting membrane potential, input resistance and fast and slow excitatory synaptic transmission.




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Copyright © 1994 by the The Physiological Society.