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Experimental Physiology 80.3 pp 491-494
© The Physiological Society 1995
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Experimental Physiology, Vol 80, Issue 3, 491-494
Copyright © 1995 by The Physiological Society

Article

The effects of MM-creatine kinase deficiency on sustained force production of mouse fast skeletal muscle

A de Haan, JC Koudijs, RA Wevers, and B Wieringa

Twitch force production was normal in muscles of mice which lack MM-creatine kinase, but the tetanic force:twitch force ratio was lower than in control muscles (3.60 vs 4.27; P < 0.05). In a series of repeated tetanic contractions the force in the second contraction was already markedly depressed (20-50%), while subsequently only small changes were observed. The effect was greater in exercise that would require a higher metabolic peak flux. The depressed force production was not accompanied by a slowing of relaxation, indicating that enough ATP was present to sustain myofibrillar ATPase and Ca(2+)-ATPase activity.


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