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Experimental Physiology 80.5 pp 865-875
© The Physiological Society 1995
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Experimental Physiology, Vol 80, Issue 5, 865-875
Copyright © 1995 by The Physiological Society

Article

Clinical aspects of hypoxic pulmonary vasoconstriction

RM Leach and DF Treacher

Although frequently unrecognized, hypoxic pulmonary vascular disease is an important cofactor in the morbidity and mortality of a wide spectrum of disease processes. The hypoxic response incorporates two distinct phases, the acute hypoxic vasoconstrictor response and vascular remodelling associated with prolonged alveolar hypoxia. Understanding of the mechanisms causing both processes has increased rapidly and may result in the near future in specific treatment aimed at correcting underlying physiological abnormalities. However, currently available therapies remain limited to correction of the hypoxaemia and generalized non-specific pulmonary vasodilatation. The recent development of inhaled NO therapy represents a significant advance in the management of the acute hypoxic pulmonary vasoconstriction occurring during critical illness.


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