Experimental Physiology
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Experimental Physiology 83.4 pp 481-487
© The Physiological Society 1998
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Experimental Physiology, Vol 83, Issue 4, 481-487
Copyright © 1998 by The Physiological Society

Article

The influence of streptozotocin-induced diabetes and the antihyperglycaemic agent metformin on the contractile characteristics and the membrane potential of the rat diaphragm

M McGuire and M MacDermott

After 2 months of streptozotocin-induced diabetes in rats, the membrane potential of the diaphragm muscle when measured in vitro at 30 degrees C was unchanged but the tetanic tension, the half-relaxation time of the isometric twitch and the fatigue resistance were each reduced. Treatment of the diabetic rats with the antihyperglycaemic agent metformin prevented the decrease in half-relaxation time and the greater degree of fatigue in the diaphragms. The possibility that changes in H+ and cyclic AMP concentrations in the diabetic muscles contributed to the decreased contractile function and that metformin acted by attenuating these changes is discussed.


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Copyright © 1998 by the The Physiological Society.