Experimental Physiology
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Experimental Physiology 83.5 pp 701-704
© The Physiological Society 1998
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Experimental Physiology, Vol 83, Issue 5, 701-704
Copyright © 1998 by The Physiological Society

Article

Chronic intermittent immobilization of male rats throughout sexual development: a stress protocol

SA Almeida, JA Anselmo-Franci, e AA Rosa Silva, and TL Carvalho

A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, caused a decrease in plasma luteinizing hormone (LH) after 15 and 60 days of immobilization and in plasma testosterone after 60 days, but produced an opposite androgenic response in pubertal animals (15 days of immobilization). A persumed sympathetic over-stimulation is suggested to account for increased testosterone levels in pubertal stressed rats.


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