Insulin sensitivity of kininogen-deficient rats was compared with that of normal rats using euglycaemic hyperinsulinaemic glucose clamping. Anaesthetized animals were infused with 2-50 mU kg-1 min-1 of insulin and the glucose infusion rates needed to maintain euglycaemia were determined. Maximum glucose uptake, insulin sensitivity index and insulin clearance were reduced in kininogen-deficient rats. Captopril increased the amount of glucose needed to maintain euglycaemia during infusion of 2 and 10 mU kg-1 min-1 of insulin in normal rats, but had no effect in kininogen-deficient rats. Anaesthetized rats of both strains were given an intraperitoneal injection of glucose and the evolution of blood glucose was followed for 120 min. The peak increase was higher in kininogen-deficient rats. Similar larger increases in blood glucose were observed after glucose injection in normal rats previously treated with HOE 140, a bradykinin B2 receptor antagonist. After glucose injection, plasma insulin increased in both groups of rats but reached lower levels in kininogen-deficient animals. These results suggest that bradykinin is involved not only in the clearance of glucose and insulin by the tissues during insulin infusion but also that bradykinin can affect the release of insulin after a glucose load.

This article has been cited by other articles:

				G. J Dietze and E. J Henriksen Review: Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis Journal of Renin-Angiotensin-Aldosterone System, June 1, 2008; 9(2): 75 - 88. [Abstract] [PDF]

				V. Wong, L. Szeto, K. Uffelman, I G. Fantus, and G. F Lewis Enhancement of muscle glucose uptake by the vasopeptidase inhibitor, omapatrilat, is independent of insulin signaling and the AMP kinase pathway. J. Endocrinol., August 1, 2006; 190(2): 441 - 450. [Abstract] [Full Text] [PDF]

				C. Cheyssac, C. Dina, F. Lepretre, V. Vasseur-Delannoy, A. Dechaume, S. Lobbens, B. Balkau, J. Ruiz, G. Charpentier, F. Pattou, et al. EIF4A2 Is a Positional Candidate Gene at the 3q27 Locus Linked to Type 2 Diabetes in French Families. Diabetes, April 1, 2006; 55(4): 1171 - 1176. [Abstract] [Full Text] [PDF]

				P. D. Taylor, J. McConnell, I. Y. Khan, K. Holemans, K. M. Lawrence, H. Asare-Anane, S. J. Persaud, P. M. Jones, L. Petrie, M. A. Hanson, et al. Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R134 - R139. [Abstract] [Full Text] [PDF]

				C. Zhao, P. Wang, X. Xiao, J. Chao, L. Chao, D. W. Wang, and D. C. Zeldin Gene Therapy With Human Tissue Kallikrein Reduces Hypertension and Hyperinsulinemia in Fructose-Induced Hypertensive Rats Hypertension, November 1, 2003; 42(5): 1026 - 1033. [Abstract] [Full Text] [PDF]

				I. Duka, S. Shenouda, C. Johns, E. Kintsurashvili, I. Gavras, and H. Gavras Role of the B2 Receptor of Bradykinin in Insulin Sensitivity Hypertension, December 1, 2001; 38(6): 1355 - 1360. [Abstract] [Full Text] [PDF]