Experimental Physiology
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Experimental Physiology 84.4 pp 601-614
© The Physiological Society 1999
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Experimental Physiology, Vol 84, Issue 4, 601-614
Copyright © 1999 by The Physiological Society

Article

Actions of the pro-inflammatory cytokine IL-1 beta on central synaptic transmission

JJ O'Connor and AN Coogan

It is now clear that IL-1 beta has profound and complex actions in the CNS. At pathophysiological concentrations it has an inhibitory effect on LTP in many regions of the hippocampus. There is also evidence emerging for a physiological role for IL-1 beta in the brain. Table 1 summarizes the effects of IL-1 beta and some other pro-inflammatory cytokines in the CNS.


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