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This Article Full Text Full Text (PDF) All Versions of this Article: 89/4/487    most recent expphysiol.2003.027029v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McCormick, K. M. Articles by Kappagoda, C. T. Search for Related Content PubMed PubMed Citation Articles by McCormick, K. M. Articles by Kappagoda, C. T. Related Collections Respiratory

Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA

The role of nitric oxide in the reflex diuresis in response to pulmonary lymphatic drainage was examined in anaesthetized, artificially ventilated New Zealand White rabbits. Pulmonary lymphatic drainage was obstructed by raising the pressure in a pouch created from the right external jugular vein. Pulmonary lymphatic obstruction resulted in a significant increase in urine flow from an initial control value of 8.9 ± 0.5 ml (10 min)^–1 to 12.1 ± 0.6 ml (10 min)^–1 during lymphatic obstruction (mean ±S.E.M.; n= 17, P < 0.001). This increase in urine flow was accompanied by a significant increase in the excretion of sodium. Additionally, renal blood flow remained unchanged during the increase in urine flow caused by lymphatic obstruction. Intravenous infusion of L-NAME, a non-selective inhibitor of nitric oxide synthase (NOS), abolished the reflex diuresis. Furthermore, intraperitoneal administration of the relatively selective neuronal NOS blocker, 7-nitroindazole also abolished the response. It was observed that infusion of a more soluble neuronal NOS blocker, 7-nitroindazole sodium salt (7-NINA), into the renal medulla also abolished the reflex diuresis. These findings suggest that the increase in urine flow in rabbits caused by pulmonary lymphatic obstruction is dependent upon the integrity of neuronal NOS activity within the renal medulla.

(Received 12 December 2003; accepted after revision 6 May 2004; first published online 6 May 2004)
Corresponding author Dr C. T. Kappagoda Division of Cardiovascular Medicine, Bioletti Way, TB 172, University of California, Davis, CA 95616, USA. Email: ctkappagoda{at}ucdavis.edu

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				K. M. McCormick, E. M. Bravo, and C. T. Kappagoda Role of adrenergic receptors in the reflex diuresis in rabbits during pulmonary lymphatic obstruction Exp Physiol, May 1, 2005; 90(3): 341 - 347. [Abstract] [Full Text] [PDF]