HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 89/4/497    most recent expphysiol.2004.027276v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Degabriele, N. M. Articles by Alton, E. W. F. W. Search for Related Content PubMed PubMed Citation Articles by Degabriele, N. M. Articles by Alton, E. W. F. W. Related Collections Heart/Cardiac Muscle

¹ Department of Gene Therapy, Faculty of Medicine at the National Heart & Lung Institute, Imperial College, London, UK and² Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA³ Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA

In order to critically evaluate the utility of a mouse model of myocardial infarction (MI) for therapeutic studies, we investigated survival, haemodynamic measurements and histopathology in mice with an occluding suture placed at one of three distinct sites along the left anterior descending coronary artery. The suture was placed at the atrioventricular juncture (High), or at two sites more distally towards the base (Middle and Low). In the High group, only 33% of animals survived 7 days after MI (P < 0.05 compared to all other groups). Only the Middle group had significantly reduced haemodynamics compared to sham-operated animals (maximum left ventricular pressure: 55.9 ± 3.5 versus 80.8 ± 5.1 mmHg, maximum change in pressure over time : 2003 ± 172 versus 4402 ± 491, P < 0.01). Histological examination showed morphological changes in all MI groups. The Middle group had larger lesions than the Low group (P < 0.05). Lesions in the anterior and lateral walls correlated, albeit weakly, with cardiac function. Power calculations indicated that, despite a certain amount of intragroup variation, the Middle Suture model may be useful for therapeutic studies to assess the effects of treatment on cardiac function and overall lesion size.

(Received 16 January 2004; accepted after revision 6 May 2004; first published online 6 May 2004)
Corresponding author U. Griesenbach: Department of Gene Therapy, Faculty of Medicine at the National Heart & Lung Institute, Imperial College, London, UK. Email: u.griesenbach{at}ic.ac.uk

This article has been cited by other articles:

				E.M. Winter, R.W. Grauss, B. Hogers, J. van Tuyn, R. van der Geest, H. Lie-Venema, R. V. Steijn, S. Maas, M.C. DeRuiter, A.A.F. deVries, et al. Preservation of Left Ventricular Function and Attenuation of Remodeling After Transplantation of Human Epicardium-Derived Cells Into the Infarcted Mouse Heart Circulation, August 21, 2007; 116(8): 917 - 927. [Abstract] [Full Text] [PDF]

				J. M. C. Lau, X. Jin, J. Ren, J. Avery, B. J. DeBosch, I. Treskov, T. S. Lupu, A. Kovacs, C. Weinheimer, and A. J. Muslin The 14-3-3{tau} Phosphoserine-Binding Protein Is Required for Cardiomyocyte Survival Mol. Cell. Biol., February 15, 2007; 27(4): 1455 - 1466. [Abstract] [Full Text] [PDF]

				T. Higuchi, S. G. Nekolla, A. Jankaukas, A. W. Weber, M. C. Huisman, S. Reder, S. I. Ziegler, M. Schwaiger, and F. M. Bengel Characterization of Normal and Infarcted Rat Myocardium Using a Combination of Small-Animal PET and Clinical MRI J. Nucl. Med., February 1, 2007; 48(2): 288 - 294. [Abstract] [Full Text] [PDF]