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This Article Full Text Full Text (PDF) All Versions of this Article: 89/6/657    most recent expphysiol.2004.027839v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Strachan, A. T Articles by Maughan, R. J Search for Related Content PubMed PubMed Citation Articles by Strachan, A. T Articles by Maughan, R. J Related Collections Human, Environmental & Exercise

¹ Department of Clinical Biochemistry, Grampian University Hospital NHS Trust, Foresterhill, Aberdeen, AB25 2ZD, UK ² School of Medical Sciences, University Medical School, Foresterhill, Aberdeen, AB25 2ZD, UK ³ School of Sport & Exercise Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK

The purpose of the experiment was to examine whether selective serotonin (5-HT) re-uptake transporter blockade by paroxetine has any effect on perceived effort (RPE) during exercise or the time to reach volitional fatigue and on the prolactin and cortisol responses during prolonged exercise performed in a warm environment. Eight healthy males performed two cycle rides to exhaustion in a warm (32°C) environment at 60% of maximum oxygen uptake. Paroxetine (20 mg) or placebo was administered 5 h before exercise trials in a randomised double blind fashion. Time to exhaustion was not significantly influenced by administration of paroxetine: median (range) time to exhaustion was 93.3 (76.2–175.0) min on the placebo trial and 92.5 (66.0–151.0) min on the paroxetine trial. Rectal temperature was higher at rest and throughout exercise on the paroxetine trial. The serum concentrations of prolactin and cortisol were determined throughout exercise as peripheral markers of central 5-HT activity. RPE increased over time but was not influenced by paroxetine administration. Prolactin and cortisol levels increased over time but paroxetine administration did not influence the hormone responses during exercise. In conclusion, acute administration of paroxetine failed to alter RPE, exercise capacity or the response of the determined peripheral hormone markers of central 5-HT activity during prolonged exercise in a warm environment.

(Received 20 April 2004; accepted after revision 17 July 2004; first published online 24 August 2004)
Corresponding author A. T. Strachan: Department of Clinical Biochemistry, Grampian University Hospital NHS Trust, Foresterhill, Aberdeen, AB25 2ZD, UK. Email: a.t.strachan{at}arh.grampian.scot.nhs.uk

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