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Experimental Physiology 89.6 pp 717-725
DOI: 10.1113/expphysiol.2004.027953
© The Physiological Society 2004
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Modulation of visceral function by selective stimulation of the left vagus nerve in dogs

J Rozman1 and M Bunc2

1 ITIS d. o. o. Ljubljana, Center for Implantable Technology and Sensors, Lepi pot 11, Republic of Slovenia 2 University of Ljubljana, School of Medicine, Institute of Pathophysiology, Zaloska 4, 1000 Ljubljana, Republic of Slovenia

The superficial regions of the left vagus nerves of a dog were selectively stimulated with 39-electrode spiral cuffs having 13 circumferential groups of three electrodes (GTE) to modulate the function of the innervated internal organs and glands. Under general anaesthesia, the cuffs were chronically implanted around the nerve in the neck in two adult Beagle dogs and remained viable for 16 months. The regions were stimulated with biphasic, rectangular current pulses (2 mA, 200 µs, 20 Hz) delivered to the group of GTE lying close to the region innervating the specific internal organs or glands. The results showed that specific electrode configurations had actions on the heart (GTE 9), lungs (GTE 4) and pressure in the urinary bladder (GTE 1). It was also shown that GTE no. 10 significantly modified the endocrine function of the pancreas. The results of this study clearly demonstrate that internal organs and glands can be selectively stimulated via the selective stimulation of innervating superficial regions of the autonomous peripheral nerve.

(Received 18 May 2004; accepted after revision 27 August 2004; first published online 13 September 2004)
Corresponding author J. Rozman: ITIS d.o.o. Ljubljana, Center for Implantable Technology and Sensors, Lepi pot 11, 1000 Ljubljana, Republic of Slovenia. Email: janez.rozman{at}guest.arnes.si






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