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This Article Full Text Full Text (PDF) All Versions of this Article: 90/1/79    most recent expphysiol.2004.028241v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by de Oliveira, C. A. M. Articles by de Mello, M. A. R. Search for Related Content PubMed PubMed Citation Articles by de Oliveira, C. A. M. Articles by de Mello, M. A. R. Related Collections Neuroendocrinology/Endocrinology

¹ Department of Physical Education, UNESP, São Paulo State University, Rio Claro, São Paulo, Brazil

The present study was designed to analyse the effects of aerobic exercise on the metabolic effects of alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight)^–1) intraperitoneally (A rats). Vehicle-injected rats were used as controls (C rats). At 28 days old, some of the A rats were subjected to swimming for 1 h day^–1, 5 day week^–1 (AT rats). At 28, 60 and 90 days old the animals were subjected to glucose (GTTo) and insulin (ITTsc) tolerance tests. All the animals were then killed by decapitation for blood and tissue evaluations. On the 60th day, there was a reduction in blood glucose level during the GTTo (mmol l^–1 (90 min)^–1) in the AT rats (7640.7 ± 694.0) with respect to C (7057.5 ± 776.9) and A (8555.6 ± 1096.7) rats. However on the 90th day, AT rats showed higher glucose levels (8004.6 ± 267.9) when compared to the other groups (C, 7305.5 ± 871.2; A, 7088.8 ± 536.9). The serum free fatty acid (FFA) concentration (µEq l^–1) was higher in the alloxan-treated animals (A, 231.1 ± 58.5; AT, 169.8 ± 20.1) than in controls (C, 101.4 ± 22.4). In conclusion, although the high blood glucose level is transitory in the A animals, some blood and tissue alterations remain and can be harmful to the maintenance of homeostasis. Physical exercise counteracted only partially these alterations. Furthermore, training worsened glucose tolerance at the 90th day, suggesting that exercise intensity should be adjusted to the diabetic condition.

(Received 4 June 2004; accepted after revision 17 September 2004; first published online 4 October 2004)
Corresponding author C. A. Machado de Oliveira: Avenue. 24 A, 1515, Departamento de Educação Física, IB, UNESP Universidade Estadual Paulista, Rio Claro, Sao Paulo, Brazil. E-mail: camo{at}rc.unesp.br