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This Article Full Text Full Text (PDF) All Versions of this Article: 90/3/273    most recent expphysiol.2004.029322v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pravenec, M. Articles by Kren, V. Search for Related Content PubMed PubMed Citation Articles by Pravenec, M. Articles by Kren, V. Related Collections Themed Issue papers Genomic Physiology

Michal Pravenec¹² and Vladimír Ken¹²

¹ Institute of Physiology, Czech Academy of Sciences and Center for Applied Genomics, Prague, Czech Republic² Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic

Identification of the genetic determinants of common diseases is a major challenge for current biomedical research. Combining linkage analyses of essentially monogenic cis-regulated expression phenotypes with oligogenic intermediate physiological phenotypes represents a promising approach for identification of quantitative trait loci at the molecular level. In the present review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described.

(Received 12 January 2005; accepted after revision 17 February 2005; first published online 22 February 2005)
Corresponding author M. Pravenec: Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic. Email: pravenec{at}biomed.cas.cz

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